It serves the same the same function as the ablative of agent (a/ab + abl) with others passive forms of the verb. We must return home, literally, It must be returned home by us.ĭative of Agent- In the passive periphrastic, the person who must perform the obligation expressed verb in the verb is found in dative case, a use known as the dative of Agent. For better English, transform the passive voice to the active. When an intransitive verb appears in the passive periphrastic, the gerundive is used impersonally, has it as the subject. This use is known as the passive periphrastic or the gerundive obligation. The gerundive plus a form of esse, provided or understood, is translated must be, should be, has to be. Semper aliqui anquirendi sunt quos diligamus- Some(people) must always be sought out whom we may hold dear.The Passive Periphrastic (Gerundive of Obligation)Įpistula eat conficienda, the letter must be finished- Conficienda, when found with the form of esse, in this situation est, expresses necessity or obligation, must Aptus, -a, -um, fit(for), suitable(for).There are also several adjectives that could be use with the Dative in situations like this. Forum est locus idoneus orationibus habendis- The Forum is a suitable place for delivering speeches."Until head-to-head clinical trial data are available, the results of our study, which included a large sample of patients seen in routine care, provides updated evidence in support of apixaban for treating nonvalvular Afib," they concluded.Adjectives with the Dative- Certain adjectives that can be completed by a noun in the Dative "The results of our study are concordant with those of the first indirect comparison among randomized controlled trials suggesting that apixaban was safer than rivaroxaban and with those of subsequent network meta-analyses," study authors maintained. Moreover, patients' outcomes were defined by diagnostic codes rather than outcome adjudication, Fralick and colleagues cautioned. The authors noted they had incomplete lab data and lacked information on over-the-counter medication use. ![]() Vasculitis rates were numerically lower with apixaban compared with rivaroxaban (1.06 vs 1.21 per 1,000 person-years).īecause this was an observational study, unmeasured confounding may have played a role in the results. In terms of rare adverse events, hepatitis was relatively common in this population, occurring at 13.1 cases per 1,000 person-years with apixaban and 12.3 cases per 1,000 person-years with rivaroxaban. The apixaban group was slightly older, more likely to have a diagnosis of kidney or cardiovascular disease, and taking slightly more medications at baseline.Īfter propensity-score matching, baseline characteristics were well-balanced between groups. The investigators found 59,172 adults newly prescribed apixaban 5 mg and 40,706 prescribed rivaroxaban 20 mg. ![]() nationwide commercial healthcare claims database from Optum (most patients within Optum are covered by employer-sponsored insurance). In Fralick's retrospective cohort study, 39,351 people with non-valvular Afib seeking routine care who were newly prescribed apixaban were propensity-score matched to the same number newly prescribed rivaroxaban and followed over an average around 290 days.Īll had been identified from a U.S. More than a year later, apixaban received the same indication from the agency. In 2011, rivaroxaban became the first DOAC to be approved by the FDA for the indication of stroke prevention in non-valvular Afib. The study wasn't initiated or funded by either drug's manufacturer. "Findings were robust across several subgroup and sensitivity analyses, including a population restricted to patients older than 70 years," the researchers wrote. ![]() Apixaban was also associated with better safety in terms of decreased incidence of intracranial hemorrhage or GI bleeding compared with rivaroxaban (12.9 vs 21.9 per 1,000 person-years, HR 0.58, 95% CI 0.52-0.66).
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